z-logo
Premium
Prevalence of H elicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in K ashmir, I ndia
Author(s) -
Sodhi Jaswinder Singh,
Javid Gul,
Zargar Showkat Ali,
Tufail Syed,
Shah Altaf,
Khan Bashir Ahmad,
Yattoo Ghulam Nabi,
Gulzar Ghulam Mohamad,
Khan Mushtaq Ahmad,
Lone Mohd Iqbal,
Saif Riyaz u,
Parveen Shaheena,
Shoukat Abid
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12178
Subject(s) - medicine , gastroenterology , omeprazole , placebo , clarithromycin , helicobacter pylori , amoxicillin , gastritis , rapid urease test , antibiotics , pathology , alternative medicine , microbiology and biotechnology , biology
Background and Aim Epidemiology of H elicobacter pylori infection has regional variation. Effect of eradication of H . pylori on symptoms of functional dyspepsia is uncertain, and the data in A sian scenario are scanty. The study aimed to see H . pylori positivity rate in patients of functional dyspepsia and the effect of its eradication on symptoms. Methods Randomized, double‐blind, placebo‐controlled study was the study design used. Patients of functional dyspepsia defined as per R ome 2 criteria were tested for H . pylori infection by rapid urease test and gastric biopsy. H . pylori ‐positive patients were randomly allocated to triple therapy (20 mg of omeprazole, 500 mg of clarithromycin, and 1000 mg of amoxicillin orally two times daily) and omeperazole plus identical placebo for 2 weeks. Symptoms were assessed with the weekly L ikert scale. Results H . pylori positivity rate in functional dyspepsia was 1160/2000 (58%). At 6 weeks, the eradication rate for H . pylori in triple therapy and placebo group was (181/259 [69.8%] and 13/260 [5.0%], P  = 0.001), respectively. On intention‐to‐treat analysis, the symptom resolution at 1 month was (157/259 [60.7%] and 136/260 [52.3%], P  = 0.38), respectively. At 12 months, H . pylori eradication and healing of gastritis in triple therapy and placebo group were (116/174 [66.7%] and 12/180 [6.7%], P  = 0.001) and (132/174 [75.9%] and 11/180 [6.1%], P  = 0.001), respectively. On intension to treat, the resolution of symptoms in triple therapy and placebo group was (95/217 [43.7%] and 72/195 [36.9%], P  = 0.13). Conclusion There is high H . pylori positivity rate in patients of functional dyspepsia. The eradication of H . pylori does not resolve the symptoms despite healing of gastritis.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here