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Incidence and clinical characteristics of inflammatory bowel disease in a developed region of G uangdong P rovince, C hina: A prospective population‐based study
Author(s) -
Zeng Zhirong,
Zhu Zhenhua,
Yang Yuyu,
Ruan Weishan,
Peng Xiabiao,
Su Yuhuan,
Peng Lin,
Chen Jinquan,
Yin Quan,
Zhao Chao,
Zhou Haihua,
Yuan Shuai,
Hao Yuantao,
Qian Jiaming,
Ng Siew Chien,
Chen Minhu,
Hu Pinjin
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12164
Subject(s) - medicine , incidence (geometry) , inflammatory bowel disease , gastroenterology , ulcerative colitis , prospective cohort study , population , epidemiology , immunology , disease , physics , environmental health , optics
Background and Aims The incidence of inflammatory bowel disease ( IBD ) is increasing in C hina with urbanization and socioeconomic development. There is however a lack of prospective, population‐based epidemiology study on IBD in C hina. The aim of the study is to define the incidence and clinical characteristics of IBD in a developed region of G uangdong P rovince in C hina. Methods A prospective, population‐based incidence study was conducted from J uly 2011 to J une 2012 in Z hongshan, G uangdong, C hina. All newly diagnosed IBD cases in Z hongshan were included. Results I n total, 48 new cases of IBD (17 C rohn's disease [ CD ]; 31 ulcerative colitis [ UC ]) were identified over a 1‐year period from J uly 2011. Age‐standardized incidence rates for IBD , UC , and CD were 3.14, 2.05, and 1.09 per 100 000 persons, respectively. The median age of UC was 38, and that of CD was 25. Terminal ileum involvement only ( L 1), isolated colonic disease ( L 2), and ileocolonic disease ( L 3) were reported in 24%, 6%, and 71% of patients with CD , respectively. Twenty‐four percent of patients had coexisting upper gastrointestinal disease ( L 4). Inflammatory ( B 1), stricturing ( B 2), and penetrating ( B 3) behavior were seen in 65%, 24%, and 12% of CD patients, respectively. Fifty‐nine percent of CD and 26% of UC patients had extra‐intestinal manifestations. Conclusions This is the first prospective, population‐based IBD epidemiological study in a developed region of C hina. The incidence of IBD is similar to that in J apan and H ong K ong but lower than that in S outh K orea and W estern countries.