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Catalase gene C ‐262T polymorphism: Importance in ulcerative colitis
Author(s) -
Khodayari Siamak,
Salehi Zivar,
Fakhrieh Asl Saba,
Aminian Keyvan,
Mirzaei Gisomi Nadia,
Torabi Dalivandan Saeideh
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12141
Subject(s) - catalase , genotype , oxidative stress , odds ratio , reactive oxygen species , ulcerative colitis , allele , medicine , gene polymorphism , case control study , immunology , gastroenterology , disease , biology , gene , genetics
Background and Aim Reactive oxygen species ( ROS ) are by‐products of the cellular metabolism and have important roles in the normal physiology of the cell. However, when ROS production exceeds the antioxidant capacity, a state known as oxidative stress, damage to cellular macromolecules emerges. A crucial role in counteracting ROS is played by the enzyme catalase. A common polymorphism in the catalase ( CAT ) promoter region ( C ‐262 T ) alters the expression as well as blood catalase levels, and leads to a number of human diseases. Ulcerative colitis ( UC ) is an inflammatory condition of the large bowel that is known to be influenced by oxidative stress. In this study, we aimed to evaluate the association of CAT C ‐262 T polymorphism on the risk of UC . Methods Samples were collected from 60 patients diagnosed with UC and 78 control subjects, and genotyped by allele‐specific polymerase chain reaction. Results We found that CAT C ‐262T genotype frequencies were significantly different between cases and controls ( P = 0.002). Individuals carrying the −262 C / T genotype had a greater risk for UC compared with C / C genotype (odds ratio, 4.88; 95% confidence interval, 1.73–13.75, P = 0.002). Conclusions This study indicates that CAT C ‐262 T polymorphism may be associated with UC , and that the −262 C / T genotype may be a risk factor for the disease. Further studies are needed to confirm the results.