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Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma
Author(s) -
Honda Yohji,
Kimura Tomoki,
Aikata Hiroshi,
Kobayashi Tomoki,
Fukuhara Takayuki,
Masaki Keiichi,
Nakahara Takashi,
Naeshiro Noriaki,
Ono Atsushi,
Miyaki Daisuke,
Nagaoki Yuko,
Kawaoka Tomokazu,
Takaki Shintaro,
Hiramatsu Akira,
Ishikawa Masaki,
Kakizawa Hideaki,
Kenjo Masahiro,
Takahashi Shoichi,
Awai Kazuo,
Nagata Yasushi,
Chayama Kazuaki
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12087
Subject(s) - medicine , hepatocellular carcinoma , transcatheter arterial chemoembolization , radiation therapy , radiology , complication , retrospective cohort study , cohort , surgery
Abstact Background and Aims To compare the tumor control and safety of stereotactic body radiation therapy ( SBRT ) combined with transcatheter arterial chemoembolization ( TACE ) for small, solitary, and hypervascular hepatocellular carcinoma ( HCC ) with TACE alone. Methods Three hundred and sixty‐five HCC patients who had solitary, ≤ 3 cm, and hypervascular nodule were treated with TACE . Among them, 30 patients followed by SBRT ( SBRT group) and 38 patients without additional therapy and previous HCC treatment (control group) were enrolled in this retrospective cohort study. Local tumor progression, complication, and disease‐free survival were compared between these groups. Results There was no difference in clinical background between these groups. Complete response to therapy was noted in 29 (96.3%) patients of the SBRT group, and in only one (3.3%) patient of the TACE group ( P < 0.001). None of the patients developed acute hematologic toxicity of more than C ommon T erminology C riteria for A dverse E vents Grade 3 during and after the treatment. Furthermore, none of the SBRT group developed radiation‐induced liver damage. Disease‐free survival of the 12 patients without previous HCC treatments in SBRT group was significantly superior to that in control group (15.7 months vs 4.2 months; P = 0.029). Conclusion The results indicated that SBRT combined with TACE is a safe and effective modality for locoregional treatment of small solitary primary HCC , and could be potentially a suitable option.