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Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection
Author(s) -
Higuchi Naomi,
Nakamura Kazuhiko,
Ihara Eikichi,
Akahoshi Kazuya,
Akiho Hirotada,
Sumida Yorinobu,
Motomura Yasuaki,
Kubokawa Masaru,
Ito Tetsuhide,
Takayanagi Ryoichi
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12086
Subject(s) - gastric emptying , medicine , gastroenterology , endoscopic submucosal dissection , cancer , stomach , surgery
Background and Aim Endoscopic submucosal dissection ( ESD ) is now accepted as a minimally invasive treatment for early gastric cancer ( EGC ). To our knowledge, however, the functional effects of ESD have not been determined in patients with EGC . We therefore investigated whether gastric motility was affected by ESD . Methods Using the 13 C ‐octanoic acid breath test, gastric emptying of solid test meals was examined in 26 EGC patients and 18 healthy controls, with EGC patients assayed before and about 2 months after ESD . Based on 13 CO 2 breath‐excretion curves, the lag‐phase time ( T lag ), half‐emptying time ( T 1/2 ), and gastric emptying coefficient ( GEC ) were calculated as indices of gastric emptying. Results In healthy controls, the mean T lag , T 1/2 , and GEC were 85.5 ± 4.9 min, 148.5 ± 8.0 min, and 3.01 ± 0.09 h, respectively. Before ESD , the mean T lag , T 1/2 , and GEC in the EGC patients were 90.1 ± 5.5 min, 174.7 ± 10.4 min, 2.64 ± 0.08 h, respectively. GEC , but not T lag or T 1/2 , differed significantly in the two groups, with gastric emptying slower in EGC patients than in controls. Relative to before ESD , the mean T lag , T 1/2 , and GEC in EGC patients after ESD were 109.2% ± 7.8%, 107.9% ± 9.6%, 108.4% ± 4.7%, respectively, indicating that ESD did not significantly affect any of these gastric emptying parameters in EGC patients. Conclusion ESD is an effective treatment for EGC both in preserving organs and gastric motility.