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The Substance Basis Research of Stir‐Baking to Dark Brown Could Enhance the Promoting Effects of Areca Nut on Gastrointestinal Motility
Author(s) -
Liu Yujie,
Peng Wei,
Hu Meibian,
Yan Dan,
Xu Min,
He Xiaoyan,
Wu Chunjie
Publication year - 2017
Publication title -
journal of food processing and preservation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.511
H-Index - 48
eISSN - 1745-4549
pISSN - 0145-8892
DOI - 10.1111/jfpp.13103
Subject(s) - motility , chemistry , maillard reaction , maltol , food science , brown rice , areca , nut , biology , genetics , structural engineering , engineering
The promoting effects of areca nut (AN) and charred areca nut (CAN) on gastrointestinal motility were compared. The HPLC analysis was used to compare the constituents in AN and CAN and the new produced constituents in CAN were isolated and identified. Then the promoting effects of the identified constituents on gastrointestinal motility were investigated in vivo . In the results, CAN showed stronger promoting effect on gastrointestinal motility than that of AN ( P < 0.05) in vivo and in vitro . Three new constituents in CAN were identified as 2,3‐dihydro‐3,5‐dihydroxy‐6‐methyl‐4H‐pyranone (DDMP), 5‐hydroxymethyl‐2‐furfural (5‐HMF) and 3‐hydroxy‐2‐methyl‐γ‐pyrone (maltol). Interestingly, AN combined with the constituents (DDMP : 5‐HMF : maltol = 30:355:21) showed a synergistic effect on promoting gastrointestinal motility. In conclusion, the results indicated that Maillard reaction products (MRPs) might be the substance basis of stir‐baking to dark brown enhances the promoting effects of AN on gastrointestinal motility. Practical Applications Stir‐baking to dark brown is a common processing technique of Traditional Chinese Medicine (TCM) in China. AN is usually processed by stir‐baking to dark brown to CAN before clinical use, because CAN was considered to be specialized in treating digestive disorders. The present study proved that stir‐baking to dark brown could enhance the promoting effects of AN on gastrointestinal motility. Furthermore, our investigation provided substance basis for clinical application of CAN regarding the digestive activity and will be conducive to further development of this drug.