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Immune‐Enhancing Activity of Polysaccharides from Gastrodia elata
Author(s) -
Bao Qinwen,
Qian Li,
Gong Cheng,
Shen Xiaozhu
Publication year - 2017
Publication title -
journal of food processing and preservation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.511
H-Index - 48
eISSN - 1745-4549
pISSN - 0145-8892
DOI - 10.1111/jfpp.13016
Subject(s) - gastrodia elata , polysaccharide , immune system , spleen , antibody , cyclophosphamide , pharmacology , traditional medicine , medicine , chemistry , immunology , biochemistry , chemotherapy , alternative medicine , pathology , traditional chinese medicine
In this study, polysaccharides were isolated from Gastrodia elata ( G. elata ) by hot water extraction. The immune‐enhancing activity of G. elata polysaccharides (GPs) was evaluated in Kunming mice, in which the concentrations of serum IL‐2, TNF‐α, IFN‐γ, immunoglobulin (Ig) G, IgA and IgM, as well as the spleen and thymus indexes of Kunming mice, were determined. Kunming mice were gavaged once daily with either cyclophosphamide (model) only or cyclophosphamide in combination with GPs (treatment) or distilled water (normal control) for 7 d. Intragastric GP administration improved the serum IL‐2, TNF‐α, IFN‐γ, IgG, IgA and IgM levels as well as the spleen and thymus indexes of Kunming mice. Therefore, GPs can be used as promising immunopotentiators. Practical Applications GPs have high immune‐enhancing activity; and therefore GPs can be used as promising immunopotentiators and of medical applications.