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Aeromonas salmonicida infects Atlantic salmon ( Salmo salar ) erythrocytes
Author(s) -
Valderrama Katherinne,
SotoDávila Manuel,
Segovia Cristopher,
Vásquez Ignacio,
Dang My,
Santander Javier
Publication year - 2019
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/jfd.13077
Subject(s) - aeromonas salmonicida , salmo , biology , microbiology and biotechnology , spleen , gill , fishery , fish <actinopterygii> , immunology
Aeromonas salmonicida subsp. salmonicida (hereafter A. salmonicida ) is the aetiological agent of furunculosis in marine and freshwater fish. Once A. salmonicida invade the fish host through skin, gut or gills, it spreads and colonizes the head kidney, liver, spleen and brain. A. salmonicida infects leucocytes and exhibits an extracellular phase in the blood of the host; however, it is unknown whether A. salmonicida have an intraerythrocytic phase. Here, we evaluate whether A. salmonicida infects Atlantic salmon ( Salmo salar ) erythrocytes in vitro and in vivo . A. salmonicida did not kill primary S. salar erythrocytes, even in the presence of high bacterial loads, but A. salmonicida invaded the S. salar erythrocytes in the absence of evident haemolysis. Naïve Atlantic salmon smolts intraperitoneally infected with A. salmonicida showed bacteraemia 5 days post‐infection and the presence of intraerythrocytic A. salmonicida . Our results reveal a novel intraerythrocytic phase during A. salmonicida infection.