Premium
Molecular biology of Macrobrachium rosenbergii nodavirus infection in giant freshwater prawn
Author(s) -
Low ChenFei,
Md Yusoff Mohd Radzi,
Kuppusamy Giva,
Ahmad Nadzri Nur Farahiyah
Publication year - 2018
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/jfd.12895
Subject(s) - biology , macrobrachium rosenbergii , virology , prawn , virus , viral replication , viral pathogenesis , capsid , infectivity , viral protein , host (biology) , genetics , fishery
Macrobrachium rosenbergii nodavirus ( Mr NV ) has been threatening the giant freshwater prawn aquaculture since 1997, causing white tail disease in the prawn species that leads to 100% lethality of the infected postlarvae . Comprehension of the viral infectivity and pathogenesis at molecular biology level has recently resolved the viral capsid protein and evidenced the significant difference in the viral structural protein compared to other nodaviruses that infect fish and insect. Cumulative researches have remarked the proposal to assert Mr NV as a member of new genus, gammanodavirus to the Nodaviridae family. The significance of molecular biology in Mr NV infection is being highlighted in this current review, revolving the viral life cycle from virus binding and entry into host, virus replication in host cell, to virus assembly and release. The current review also highlights the emerging aptamers technology that is also known as synthetic antibody, its application in disease diagnosis, and its prophylactic and therapeutic properties. The future perspective of synthetic virology technology in understanding viral pathogenesis, as well as its potential in viral vaccine development, is also discussed.