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Efficacy and toxicity of praziquantel in helminth‐infected barbel ( Barbus barbus L.)
Author(s) -
Zuskova E,
Piackova V,
Machova J,
Chupani L,
Steinbach C,
Stara A,
Velisek J
Publication year - 2018
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/jfd.12764
Subject(s) - praziquantel , barbel , biology , barbus , opisthorchis viverrini , toxicity , glutathione , pharmacology , cyprinidae , medicine , immunology , fishery , liver fluke , biochemistry , helminths , fish <actinopterygii> , enzyme , schistosomiasis
This study evaluated efficacy and toxicity of the pyrazinoisoquinoline anthelmintic praziquantel ( PZQ ) in barbel infected with metacercariae of Diplostomum spathaceum and adult Pomphorhynchus laevis, and assessed antioxidant biomarkers and the lipid peroxidation response in juvenile barbel post‐treatment. The estimated 96‐hr LC 50 of PZQ was 28.6 mg/L. For evaluation of efficacy, barbel naturally infected with D. spathaceum were exposed to a 10 and 20 mg/L PZQ 4‐day bath treatment. Both concentrations were 100% effective against D. spathaceum and significantly ( p < .01) affected the activity of catalase, superoxide dismutase, glutathione reductase and glutathione‐S‐transferase as well as levels of reduced glutathione in liver and muscle. The efficacy of orally administered PZQ was assessed in adult barbel naturally infected with P. laevis . Fish were administered 10, 30 and 50 mg/kg of body weight and examined via gut dissection after 6 days. The 50 mg/kg dose significantly decreased the intensity of infection. Praziquantel is a feasible bath treatment for barbel infected with D. spathaceum and has potential for oral treatment of broodfish infected with P. laevis .