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Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS‐CoV‐2?
Author(s) -
Khezri Mohammad Rafi,
GhasemnejadBerenji Morteza,
Moloodsouri Donya
Publication year - 2022
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.14212
Subject(s) - hesperetin , replication (statistics) , pi3k/akt/mtor pathway , covid-19 , protein kinase b , virology , computational biology , chemistry , biology , microbiology and biotechnology , medicine , signal transduction , biochemistry , flavonoid , antioxidant , disease , infectious disease (medical specialty)
Hesperetin, mainly found in citrus honey, has antioxidant, anti‐inflammatory, and antiviral properties. Recently, the effect of hesperetin on different aspects of SARS‐CoV‐2 infection such as viral entry, replication, and inflammatory responses has attracted a lot of attention. However, the exact molecular mechanism for its effects on SARS‐CoV‐2 infection is not stated. The PI3K/AKT signaling pathway is an intracellular pathway involved in cell proliferation, protein synthesis, and response to environmental changes. Since the role of this pathway in the pathogenesis of SARS‐CoV‐2 has recently been considered, this letter assumes the probable role of this pathway in the function of hesperetin against SARS‐CoV‐2 infection. Practical applications In this paper, we have discussed the therapeutic effects of hesperetin on SARS‐CoV‐2 infection. Additionally, we have hypothesized the molecular mechanism of hesperetin in suppression of SARS‐CoV‐2 entry to the host cells, its replication and inhibition of inflammatory responses. Based on this evidence, the pharmacological properties of hesperetin make this natural compound a potential treatment for suppression of SARS‐CoV‐2 entry into host cells and the subsequent replication of viral particles.