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Lactobacillus plantarum HFY09 alleviates alcohol‐induced gastric ulcers in mice via an anti‐oxidative mechanism
Author(s) -
Wu Ya,
Chen Hong,
Zou Yujie,
Yi Ruokun,
Mu Jianfei,
Zhao Xin
Publication year - 2021
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.13726
Subject(s) - superoxide dismutase , glutathione peroxidase , sod2 , glutathione , malondialdehyde , chemistry , oxidative stress , gpx1 , lactobacillus plantarum , catalase , biochemistry , medicine , biology , enzyme , lactic acid , bacteria , genetics
The protective effect of Lactobacillus plantarum HFY09 (LP‐HFY09) on alcohol‐induced gastric ulcers was investigated. Gastric morphology observation and pathological tissue sections showed that LP‐HFY09 effectively relieved gastric tissue injury. The biochemical indicator detection showed that LP‐HFY09 increased superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), glutathione (GSH), prostaglandin E2 (PGE2), and somatostatin (SS) levels, and decreased malondialdehyde (MDA) levels. Moreover, LP‐HFY09 inhibited the levels of inflammatory cytokines interleukin (IL)‐1β, IL‐6, and tumor necrosis factor‐α (TNF‐α), and elevated the level of anti‐inflammatory cytokine IL‐10. The quantitative polymerase chain reaction (q‐PCR) examination revealed that LP‐HFY09 enhanced the mRNA expression of nuclear factor E2‐related factor 2 (Nrf2) and downstream genes, including copper/zinc superoxide dismutase (SOD1), heme oxygenase‐1 (HO‐1), gamma‐glutamylcysteine synthetase (GSH1), manganese superoxide dismutase (SOD2), catalase (CAT), and GSH‐Px. This study indicated that LP‐HFY09 alleviated alcohol‐induced gastric ulcers by increasing gastric mucosa defense factor, and inhibiting oxidative stress and the inflammatory response. Practical applications LP‐HFY09 has the potential to be investigated as a treatment for gastric injury induced by alcohol.