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Appraisal of anti‐Parkinson activity of rhinacanthin‐C in haloperidol‐induced parkinsonism in mice: A mechanistic approach
Author(s) -
Saleem Uzma,
Gull Zujajah,
Saleem Ammara,
Shah Muhammad Ajmal,
Akhtar Muhammad Furqan,
Anwar Fareeha,
Ahmad Bashir,
Panichayupakaranant Pharkphoom
Publication year - 2021
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.13677
Subject(s) - parkinsonism , pharmacology , haloperidol , parkinson's disease , medicine , dopamine , malondialdehyde , motor coordination , superoxide dismutase , oxidative stress , disease , psychiatry
This study aimed to appraise the anti‐Parkinson's potential of rhinacanthin‐C (RC). RC (5, 10, and 20 mg/kg) was orally administered for 25 days in albino mice to treat haloperidol‐induced parkinsonism (1 mg/kg). RC significantly ( p < .05) improved the motor symptoms in block, bar, rotarod, and balance beam walking tests in treated mice. RC reduced the cataleptic effect dose‐dependently. The RC therapy notably ( p < .001) enhanced reduced glutathione, catalase, and superoxide dismutase levels while decreased malondialdehyde and nitrite levels in the tissue homogenates of the treated mice. The RC therapy significantly ( p < .01–.001) restored the dopamine, norepinephrine, and serotonin levels in the brain tissue of treated mice as co‐evidenced from brain histology. RC did not adversely affect complete blood count, and liver and kidney function tests. Taken together, these results have shown that RC is effective in treating motor and non‐motor symptoms of Parkinson’s disease. Practical applications Rhinacanthus nasutus is a medicinally rich plant that has folklore use in several ailments. The plant possessed multiple pharmacological activities due to the presence of naphthoquinones. The major compound of this plant rhinacanthin‐C was used in the present study to evaluate it's anti‐Parkinson's activity. The results provide scientific evidence of the anti‐Parkinson's potential of rhinacanthin‐C that support the use of R. nasutus leaves in the prevention and treatment of Parkinson’s disorder.