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Aqueous extract of Paullinia cupana attenuates renal and hematological effects associated with ketoprofen
Author(s) -
Belló Caroline,
Prestes Ana Paula,
Schemberger Josiane Aparecida,
Hacke Ana Carolina Mendes,
Pereira Romaiana Picada,
Manente Francine Alessandra,
Carlos Iracilda Zeppone,
Andrade Cleverton Roberto,
Fernandes Daniel,
Cruz Ivana Beatrice Manica,
Unfer Taís Cristina,
Vellosa José Carlos Rebuglio
Publication year - 2021
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.13560
Subject(s) - ketoprofen , pharmacology , chemistry , uric acid , caffeine , traditional medicine , medicine , biochemistry , endocrinology
This study aimed to evaluate the effect of aqueous extract of Paullinia cupana (AEG) against ketoprofen side effects, through biochemical, hematological, and histological parameters. AEG showed antioxidant activity in the DPPH • scavenging (IC 50 = 17.00 ± 1.00 µg/ml) and HPLC analysis revealed that this extract is constituted by antioxidants (caffeine, catechins, theobromine, and polyphenols). In vivo experiments in female Wistar rats demonstrated that alterations in urea, creatinine, and uric acid levels promoted ( p < .05) by ketoprofen were reversed when AEG was co‐administered. Ketoprofen significantly decreased the catalase levels of animal tissues ( p < .05), which were restored when AEG was co‐administered with the mentioned drug. Histological analysis showed that AEG protected tissues from damages caused by ketoprofen. Moreover, AEG reestablished the number of white blood cells, which had decreased when ketoprofen was administered. In conclusion, this study suggested that the association between ketoprofen and AEG may be an alternative to reduce health damages caused by this drug. Practical applications Paullinia cupana , popularly known as guaraná, is commonly consumed as a beverage in Brazil and exhibits pharmacological and beneficial effects to humans. Ketoprofen is an efficacious drug employed in the treatment of inflammatory processes. However, this drug can cause several side effects in humans. Thus, the usage of natural products and plant extracts that can reduce such undesirable effects consists in a valuable strategy to be applied in therapeutic interventions.