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Malus hupehensis leaves extract attenuates obesity, inflammation, and dyslipidemia by modulating lipid metabolism and oxidative stress in high‐fat diet‐induced obese mice
Author(s) -
Wu Ya,
Sun Hailan,
Yi Ruokun,
Liao Xiangping,
Li Jia,
Li Honggang,
Tan Fang,
Zhao Xin
Publication year - 2020
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.13484
Subject(s) - dyslipidemia , oxidative stress , medicine , endocrinology , malus , obesity , inflammation , lipid metabolism , glutathione , diet induced obese , downregulation and upregulation , chemistry , biology , biochemistry , insulin resistance , enzyme , ecology , gene
Malus hupehensis leaves (MHL) are used to make traditional Chinese tea. In this study, MHL extract was shown to improve metabolic disorders and inflammatory response in high‐fat diet‐induced obese mice. MHL extract could reduce body weight, and significantly alleviate liver damage and fat accumulation. MHL extract caused a decrease in the levels of ALT, AST, AKP, TC, TG, LDL‐C, and an increase in the level of HDL‐C. It also caused a decrease in inflammatory cytokines, including TNF‐α, IFN‐γ, IL‐1β, IL‐6, and an increase in the anti‐inflammatory cytokine IL‐10 and IL‐4. MHL extract could upregulate mRNA expression of PPAR‐α, LPL, CPT1, CYP7A1, SOD1, SOD2, CAT, GSH1, and GSH‐Px and downregulate that of PPAR‐γ and C/EBP‐α in the liver of obese mice. In conclusion, our work represents the first study demonstrating that MHL extract possesses an anti‐obesity effect and alleviates obesity‐related symptoms, including dyslipidemia, chronic low‐grade inflammatory, and liver damage. Practical applications The research may contribute to the development and application of MHL as functional foods or dietary supplement to fight against obesity.