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Naringenin alleviates cognition deficits in high‐fat diet‐fed SAMP8 mice
Author(s) -
Zhou Tao,
Liu Long,
Wang Qiulian,
Gao Ying
Publication year - 2020
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.13375
Subject(s) - naringenin , neuroinflammation , oxidative stress , morris water navigation task , pharmacology , cognitive decline , chemistry , endocrinology , psychology , medicine , flavonoid , neuroscience , cognition , disease , biochemistry , antioxidant , dementia
Naringenin is a natural dihydro flavonoid that is abundant in grapefruit. Previous studies suggested the cognition protective effect of naringenin in various cognitive deficits models, such as type 2 diabetic rat model and chemicals (e.g., lipopolysaccharide, scopolamine) treated rodents. However, the effects of naringenin on aging animals and the potential mechanisms are still unclear. In this study, we investigated the influence of naringenin administration on learning deficits in aging mice. High‐fat diet‐fed SAMP8 mice were employed as an age‐related model of Alzheimer's disease. Dietary administration of 0.2% naringenin for 12 weeks significantly improved the spatial learning and memory performance of the high‐fat diet‐fed SAMP8 mice in both Barnes Maze test and Morris Water Maze test. Further mechanism research indicated that naringenin reduced Aβ production, tau‐hyperphosphorylation, oxidative stress, and neuroinflammation in the brain. This research provides further evidence for the treatment effect of naringenin on Alzheimer's disease. Practical applications Naringenin, also known as 4′,5,7‐thrihydroxyflflavanone, is a natural dihydro flavonoid that is abundant in grapefruit and other citrus fruits. The current study first demonstrated the improvement effect of naringenin on cognition deficits in HFD‐fed SAMP8 mice, an aging mouse model. Potential mechanisms were also systematically explained by exploring the amyloid‐β (Aβ) accumulation, tau hyperphosphorylation, oxidative stress, and neuroinflammation in the brain of mice. This study provides further evidence for the utilization of naringenin as an effective treatment agent for Alzheimer's disease.