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Mutagenic effect of imidacloprid insecticide: The ameliorative effect of pre and post exposure to olive oil
Author(s) -
Mohamed Wafaa H.,
Amein Karam A.,
Yahia Doha,
Sharkawy Ahmed A.,
Mahmoud Adel S.
Publication year - 2020
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.13221
Subject(s) - imidacloprid , micronucleus test , olive oil , chemistry , toxicology , toxicity , pharmacology , food science , medicine , biology , pesticide , agronomy , organic chemistry
Imidacloprid, a systemic chloro–nicotinyl insecticide belong to neonicotinoid insecticides. In this study 120 rats were divided into four groups, the first group used as a control group, the second group was administered imidacloprid at a dose of 22.5 mg/kg b.w. for 4, 8, and 12 weeks. The third group was treated with olive oil (OLO) in a dose of 10 ml/kg body weight for 2 weeks before the oral dose of imidacloprid for 4, 8, and 12 weeks. The fourth group was given OLO in a dose of 10 ml/kg b.w. for 2 weeks after exposure to imidacloprid for 4, 8, and 12 weeks. Bone marrow was collected for micronucleus and chromosomal aberrations assays. The results revealed that imidacloprid induced a mutagenic effect in the 8 th and 12 th weeks of exposure and OLO decreased the mutagenic effect of imidacloprid in albino rats but not completely revert them to normal. Practical applications Using OLO as a protective or therapeutic agent due to it has an ameliorative effect on mutagenicity induced by IMI.