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Zingiber officinale extract and omega‐3 fatty acids ameliorate endoplasmic reticulum stress in a nonalcoholic fatty liver rat model
Author(s) -
Kandeil Mohamed A.,
Hashem Reem M.,
Mahmoud Mohamed O.,
Hetta Mona H.,
Tohamy Mohamed A.
Publication year - 2019
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.13076
Subject(s) - zingiber officinale , unfolded protein response , endoplasmic reticulum , xbp1 , fatty liver , endocrinology , nonalcoholic fatty liver disease , medicine , fatty acid , chop , omega 3 fatty acid , triglyceride , insulin resistance , biology , cholesterol , diabetes mellitus , chemistry , biochemistry , traditional medicine , disease , polyunsaturated fatty acid , docosahexaenoic acid , rna , rna splicing , gene
Abstract Endoplasmic reticulum (ER) stress was reported to play a major role in non‐alcoholic fatty liver disease (NAFLD) induction and progression. Here, we study the effect of Zingiber officinale and omega‐3 fatty acids on ER stress for treating NAFLD. Male Wistar rats were fed on a normal diet (control group) or high‐fat diet (HFD) for 8 weeks. The HFD rats were later treated with vehicle, omega‐3 or with Z. officinale extract. HFD group demonstrated significantly more body weight gain and higher plasma lipid profile, glucose, and hepatic enzymes. The expressions of lipogenic ChREBP and ER stress genes CHOP, XBP1, and GRP78 were increased. This was accompanied by intrahepatic fat accumulation visualized by hepatic morphology and H&E‐stained sections. Treatment with Z. officinale and omega‐3 fatty acids reverted these changes into a normal healthy state. From these results, we prove that both therapeutic approaches can be potential drugs for treating NAFLD besides other ER stress‐associated diseases. Practical applications The effect of Zingiber officinale extract and omega‐3 fatty acid on ER stress associated with NAFLD was investigated. The results revealed that Z. officinale extract and omega‐3 fatty acids significantly inhibited ER stress and intrahepatic fat accumulation with the upper hand for Z. officinale extract. Both can be used as future promising therapies for the treatment of NAFLD patients and also treating different diseases that involve ER stress as a pathological modulator like diabetes mellitus, Alzheimer's disease, Parkinson's disease, and cancer.