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Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl 4 ‐induced hepatotoxicity in Wistar rats
Author(s) -
Marques Tamara R.,
Caetano Aline A.,
Henrique S. Cesar Pedro,
Braga Mariana A.,
Henrique A. Machado Gustavo,
de Sousa Raimundo V.,
Corrêa Angelita D.
Publication year - 2018
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.12670
Subject(s) - antioxidant , chemistry , carbon tetrachloride , superoxide dismutase , food science , reactive oxygen species , biochemistry , pharmacology , organic chemistry , biology
The current study evaluated the antioxidant and hepatoprotective potential of the lyophilized extract of acerola bagasse (EAB), which is a residue from the processing of the fruit (rich in phenolic compounds), against the toxic action of carbon tetrachloride (CCl 4 ) in Wistar rats. The rats were divided into six groups of six animals and received the treatments by gavage once a day, for 21 days. The treatments with EAB containing 7 and 14 mg of phenolic compounds/kg animal weight (AW) presented a decrease in the activity of aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase, and an increase in superoxide dismutase, total antioxidant capacity and albumin content in relation to treatment with water and CCl 4 . It is concluded that the EAB has antioxidant and hepatoprotective action, at doses of 7 and 14 mg of phenolic compounds/kg AW, with possible applications in pharmaceutical, cosmetics, and food industries. Practical application Agro‐industrial wastes are promising sources of phytochemicals beneficial to health, as the phenolic compounds. Phenolic compounds prevent the action of reactive species in the human body, as well as the onset of various diseases. In this study, extract of acerola bagasse possess antioxidant and hepatoprotective actions due to the presence of phenolic compounds. The extract was able to reduce the levels of alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transferase and increase in total antioxidant levels in plasma. Thus, the acerola bagasse is a source phenolic compounds, whose extract might be able to fight reactive oxygen and nitrogen species.