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Antioxidant, brine shrimp lethality and analgesic properties of propolis from Bangladesh
Author(s) -
Tanvir E. M.,
Sakib Hossen Md.,
Mahfuza Shapla Ummay,
Mondal Milon,
Afroz Rizwana,
Mandal Manoj,
Alamgir Zaman Chowdhury M.,
Ibrahim Khalil Md.,
Hua Gan Siew
Publication year - 2018
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.12596
Subject(s) - propolis , brine shrimp , antioxidant , chemistry , polyphenol , ascorbic acid , pharmacology , traditional medicine , natural product , antimicrobial , food science , bioassay , analgesic , biochemistry , biology , medicine , organic chemistry , genetics
Abstract Propolis which is a natural resinous product from the honeybees, is becoming increasingly popular for its diverse therapeutic and industrial applications. In this study, we report for the first time the antioxidant, cytotoxic, and antinociceptive activities of propolis from Bangladesh (BDP). The antioxidant activities were measured by biochemical analyses while cytotoxicity was evaluated by brine shrimp lethality bioassay. Analgesic activity was evaluated by tail immersion and acetic acid‐induced writhing models in mice. BDP contained higher concentrations of polyphenols, flavonoids, tannins, ascorbic acid, vitamin E, and reducing sugars, as compared to previous reports of propolis from several countries. BDP also exhibited higher free radical‐scavenging activities and a dose‐dependent reducing power activity indicating its superior antioxidant potential. Moreover, BDP extract was most toxic to brine shrimp nauplii, with 50% lethal concentration (LC 50 ) of 57.99 µg/mL and exhibited considerable antinociceptive activities which may be mediated via central and peripheral inhibitory mechanisms. Practical applications BDP is a honeybee product, becoming increasingly popular due its potential contributions to human health. BDP is a rich source of natural antioxidants which has the potential to be used to ameliorate oxidative stress disorders and has useful antinociceptive activities. It may be useful as potential therapeutic agents against cancer, pesticidal agents, and for other cytotoxic uses.