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Protective effect of dietary fiber from sweet potato ( Ipomoea batatas L.) against lead‐induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways
Author(s) -
Zhang Yi,
Gu WenLong,
Duan LiQin,
Zhu Hong,
Wang HongYun,
Wang Jing,
Sun Jian,
Niu FuXiang
Publication year - 2018
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.12513
Subject(s) - chemistry , ampk , oxidative stress , malondialdehyde , superoxide dismutase , food science , reactive oxygen species , biochemistry , amp activated protein kinase , protein kinase a , kinase
Abstract Dietary fiber (DF) is the main component of sweet potato residue, which has a variety of health benefits. However, the preventive effect of DF from sweet potato on lead (Pb)‐induced renal injury remains unclear. This study identified the proximate composition and chemical components of DF extracted by ultrasound‐assisted enzymatic hydrolysis. The administration of ordinary dietary fiber (ODF) and high‐soluble dietary fiber (HSDF) decreased the blood and kidney Pb concentrations of Pb‐exposed mice. Moreover, profound Pb‐induced elevations of reactive oxygen species, malondialdehyde level, and depletion of intracellular glutathione level in kidney were suppressed by treatment with HSDF. Compared to the ODF group, HSDF activated AMP‐activated protein kinase (AMPK)/silent information regulator T1 (SIRT1)/peroxisome proliferator‐activated receptor‐γ coactivator 1α (PGC1α) signaling in kidney, which directly regulates superoxide dismutase (SOD) and nuclear respiratory factors (NRF1)/mitochondrial transcription factor A (TFAM). In conclusion, HSDF supplementation ameliorates Pb‐induced renal injury by inhibiting oxidative stress. Practical applications In China, sweet potato residue is discarded as waste, which causes environmental pollution. Sweet potato residue can be a cheap and widely available resource of DF, which was extracted by ultrasound‐assisted enzymatic hydrolysis. This study provides biological evidence that supports the use of DF from sweet potato to prevent Pb accumulation and protect the kidney, thereby indicating that DF has a great potential to be used as natural Pb‐excreting agent and functional ingredient in food products.