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Beneficial effect of catechin and epicatechin on cognitive impairment and oxidative stress induced by extremely low frequency electromagnetic field
Author(s) -
Gao QingHan,
Cai Qian,
Fan Yanna
Publication year - 2017
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.12416
Subject(s) - catechin , oxidative stress , chemistry , antioxidant , catalase , superoxide dismutase , pharmacology , nitric oxide , biochemistry , food science , medicine , polyphenol , organic chemistry
Abstract This study aimed to explore the effects of catechin and epicatechin on the cognitive deficits and oxidative damage of mice at extremely low frequency electromagnetic field (ELF‐EMF) exposure (50 Hz, 200 µT, 30 days). The results showed 90 mg/kg catechin and epicatechin treatment could keep proper body weight compared with ELF‐EMF group. Water maze test indicated learning and memory abilities of ELF‐EMF group deteriorated significantly compared with control group, but ELF‐EMF + (catechin and epicatechin) 90 group improved learning and memory abilities compared with ELF‐EMF group. Malonaldehyde (MDA) and nitric oxide (NO) increased remarkably, while catalase (CAT) and superoxide dismutase (SOD) activities decreased significantly in ELF‐EMF group. Catechin and epicatechin (90 mg/kg) administration decreased MDA and NO levels and significantly increased CAT and SOD activities. The results suggested catechin and epicatechin can be beneficial for learning and memory impair and reducing oxidative stress under ELF‐EMF exposure through scavenging free radicals and increasing antioxidant enzyme activities. Practical applications Considerable public and scientific concern was raised when researches have shown the impact of extremely low frequency electromagnetic field (ELF‐EMF) on cognition, nervous system function and brain activity. Catechin and epicatechin are widely distributed in tea, fruits and vegetables. This study highlights that catechin and epicatechin can attenuate these abnormal oxidative damage and related learning and memory deficits induced by ELF‐EMF exposure. Knowledge generated in this study will be beneficial in developing catechin and epicatechin as the candidates for treating the neurological and neurodegenerative disorders induced by ELF‐EMF exposure.