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Short‐term phlorizin treatment attenuates adipose tissue inflammation without alerting obesity in high‐fat diet fed mice
Author(s) -
Tian Yuan,
Gao Ling,
Guo Yan,
Xu Yancheng
Publication year - 2017
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.12407
Subject(s) - phlorizin , adipose tissue , inflammation , endocrinology , medicine , chemistry , biology , glucose transporter , insulin
Phlorizin is a member of the chalcone class of organic compounds that was originally extracted from apples. The aim of the study was to investigate the attenuation effect of phlorizin on adipose tissue inflammation in high‐fat diet fed obese mice. The results showed that 0.02% phlorizin dietary treatment in high fat diet fed mice for 6 weeks significantly reduced concentration of serum and adipose tissue pro‐inflammation cytokines, including MCP‐1, TNF‐α, IL‐1, IL‐6, and IL‐1β without altering body fat and serum lipid levels. Phlorizin inhibited inflammation related pathways: c‐Jun N‐terminal kinase and nuclear factor κB (NFκB) pathways, down‐regulated the protein expression of macrophage maker F4/80 and M1 macrophage marker CD11c, up‐regulated the protein expression of M2 macrophage marker CD206 in adipose tissue. This research provides novel insight into the treatment effect of phlorizin in obesity related inflammation. Practical applications Phlorizin, a member of the chalcone class of organic compounds especially abundant in apples has been used in human medicine for long because of its extensive bioactivities, such as anti‐diabetes and antioxidation. This study demonstrated that phlorizin inhibited adipose tissue inflammatory response in HFD‐fed obese mice via inhibition of c‐Jun N‐terminal kinase and IKK‐β/NFκB pathways, reduction of macrophage infiltration and regulation of M1/M2 macrophage polarization. Phlorizin can be a practical bioactive compound on attenuating obesity related inflammation and metabolic disorders.