Premium
Therapeutic Potential of Myrtus communis Subsp. communis Extract Against Acetic ACID‐Induced Colonic Inflammation in Rats
Author(s) -
Sen Ali,
Yuksel Meral,
Bulut Gizem,
Bitis Leyla,
Ercan Feriha,
OzyilmazYay Nagehan,
Akbulut Ozben,
Cobanoğlu Hamit,
Ozkan Sevil,
Sener Goksel
Publication year - 2017
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.12297
Subject(s) - myrtus communis , myeloperoxidase , colitis , pharmacology , chemistry , acetic acid , glutathione , malondialdehyde , biochemistry , inflammation , antioxidant , traditional medicine , medicine , food science , immunology , enzyme , essential oil
The aim of this study was to evaluate the effect of ethanol extract from leaves of Myrtus communis subsp. communis (MC) on acetic acid (AA)‐induced ulcerative colitis in rats. On the fourth day of colitis induction, all rats were decapitated. Colitis was assessed by macroscopic and microscopic scores and by measuring malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity, luminol, lucigenin, nitric oxid and peroxynitrite chemiluminescence (CL). Colitis caused significant increases in the colonic MDA levels, MPO activity, CL values, macroscopic and microscopic damage scores along with significant decrease in tissue GSH level. However, treatment with MC extract reversed all these biochemical indices, as well as histopathological alterations induced by AA with the protective effects being similar to that of sulphasalazine treatment. The study showed that MC extract could alleviate colitis in rats and can be considered an alternative therapeutic approach for management of inflammatory bowel diseases (IBD). Practical Applications Myrtus communis subsp. communis leaves are used as antihypertensive, antitussive, antiemetic, diuretic, antidiarrheic, cardiotonic, antidiabetic and anti‐inflammatory agents in folk medicine. This study revealed that the ethanol extract of the plant possesses significant anti‐inflammatory activity, confirming its traditional use.