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A Bioactive Constituent of Ginger, 6‐Shogaol, Prevents Adipogenesis and Stimulates Lipolysis in 3 T 3‐ L 1 Adipocytes
Author(s) -
Suk Sujin,
Seo Sang Gwon,
Yu Jae Gak,
Yang Hee,
Jeong Eunsun,
Jang Young Jin,
Yaghmoor Soonham Sami,
Ahmed Youssri,
Yousef Jehad Mustafa,
Abualnaja Khalid Omer,
AlMalki Abdulrahman Labeed,
Kumosani Taha Abdullah,
Lee Chang Y.,
Lee Hyong Joo,
Lee Ki Won
Publication year - 2016
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.12191
Subject(s) - adipogenesis , lipolysis , 3t3 l1 , gingerol , zingiber officinale , chemistry , obesity , in vitro , food science , adipose tissue , traditional medicine , biochemistry , biology , endocrinology , medicine
Z ingiber officinale R oscoe, one of the most widely used spices, has been reported to have anti‐obesity and anti‐diabetes effects. In the present study, we investigated the effects of 6‐shogaol, a bioactive compound present in ginger, on the adipogenic process in 3 T 3‐ L 1 preadipocytes. The anti‐adipogenic effects of 6‐shogaol was significantly higher than the more widely investigated 6‐gingerol, another major ginger constituent. We observed that 6‐shogaol inhibited the expression of two master regulators of adipogenesis, PPAR γ and C / EBP α, and also stimulated lipolysis in mature 3 T 3‐ L 1 adipocytes. Collectively, these results suggest that 6‐shogaol, not 6‐gingerol, is the major compound present in ginger responsible for its reported anti‐adipogenic properties. Practical Applications Ginger is widely consumed all over the world, and has been associated with various health benefits. At least some of these benefits have been previously attributed to 6‐gingerol. In the present study, we observed that 6‐shogaol has more potent anti‐adipogenic effects than 6‐gingerol in 3 T 3‐ L 1 cells. This is the first study to investigate the anti‐obesity effect of 6‐shogaol in vitro , and provides a new perspective on future development of ginger‐based anti‐obesity strategies.