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Antioxidant, Anti‐Inflammatory, Acetylcholinesterase Inhibitory and Antimicrobial Activities of T urkish Endemic C entaurea antiochia var. P raealta
Author(s) -
Ozsoy Nurten,
Kultur Sukran,
YilmazOzden Tugba,
Ozbek Celik Berna,
Can Ayse,
Melikoglu Gulay
Publication year - 2015
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.12143
Subject(s) - acetylcholinesterase , antimicrobial , antioxidant , traditional medicine , turkish , pharmacology , chemistry , biology , medicine , enzyme , biochemistry , microbiology and biotechnology , linguistics , philosophy
The antioxidant, anti‐inflammatory, acetylcholinesterase ( AChE ) inhibitory and antimicrobial activities of extract from the C entaurea antiochia B oiss. var. praealta ( B oiss. & B al.) W agenitz, an endemic plant species from T urkey, were investigated. The results indicated that the extract inhibits FeCl 3 /ascorbic acid‐induced phosphatidylcholine liposome oxidation, scavenges stable 2,2‐diphenyl‐1‐picrylhydrazyl ( DPPH ) and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) ( ABTS ) cation radicals, and reduces Fe 3+ to Fe 2+ in the ferric‐reducing antioxidant power ( FRAP ) assay. The extract inhibited AChE and both cyclooxygenase ( COX )‐1 and COX ‐2, which suggests this species might be a potential source of plant‐derived anti‐inflammatory and anti‐ AChE substances. The extract may also act as an antimicrobial agent because it inhibited the growth of G ram‐positive and G ram‐negative bacteria as well as yeast. These findings may scientifically explain some uses of this species in T urkish folk medicine as an antimicrobial, anti‐inflammatory and wound healing agent. Practical Applications The C entaurea species are known by the vernacular name “peygamber çiçeği” in T urkish folk medicine. Ethnobotanical reports indicate the C entaurea species have antidiabetic, anti‐inflammatory, wound healing, digestive, stomachic, diuretic, astringent, hypotensive, antipyretic, laxative, analgesic, tonic, hemostatic and antibacterial properties. Considering the important role oxidative stress and inflammation play in the pathogenesis of neurological diseases, C . antiochia var. praealta may be used as a medicinal plant to treat A lzheimer's disease. This study also confirms the efficacy of this plant as a natural antimicrobial agent.