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Impact of Chicory‐Supplemented Diet on HMG ‐ CoA Reductase, Acetyl‐ CoA Carboxylase, Visfatin and Anti‐Oxidant Status in T riton WR ‐1339‐Induced Hyperlipidemia
Author(s) -
Keshk Walaa A.,
Noeman Saad A.
Publication year - 2015
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/jfbc.12115
Subject(s) - cichorium , hyperlipidemia , medicine , steatosis , lipid profile , endocrinology , hmg coa reductase , superoxide dismutase , cholesterol , reductase , chemistry , biochemistry , biology , enzyme , oxidative stress , botany , diabetes mellitus
Hyperlipidemia is a major risk factor for cardiovascular diseases. The present study was conducted to evaluate the potential role of chicory ( Cichorium intybus Linn.) against hyperlipidemia and its subsequent effect in rats. Sixty male albino rats were randomly and equally divided into four groups. Hyperlipidemia was induced via intraperitoneal injection of T riton WR ‐1339 at a dose of 250 mg/kg body weight three times a week for 2 weeks. Chicory‐supplemented diet (10 g/100 g diet) was given for 4 weeks to group II and group IV . Chicory caused significant improvement in lipid profile and decreased the liver and heart acetyl‐ CoA carboxylase activity, atherogenic indices, hepatic 3‐hydroxy‐3‐methylglutaryl coenzyme A ( HMG ‐ CoA ) reductase mRNA level and visfatin level. Meanwhile, significant increase in paraoxonase‐1, superoxide dismutase and catalase activity was recorded. In conclusion, chicory has the potential role of being hypolipidemic, anti‐lipotoxic, anti‐oxidant and anti‐atherogenic factor. Practical Applications Herbal treatments for hyperlipidemia are relatively cheap and locally available. The results showed that chicory ( Cichorium intybus ) has the potential of being hypolipidemic, anti‐oxidant, anti‐inflammatory, and decreased the atherogenic risk indices and anti‐steatotic. Thus, it may represent a new source of natural food supplement aimed at preventing dyslipidemic risk for atherosclerosis, cardiac and hepatic steatosis.