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The cycling gonad: retinoic‐acid synthesis and degradation patterns during adult zebrafish Danio rerio oogenesis
Author(s) -
Ruivo R.,
Capitão A.,
Castro L. F. C.,
Santos M. M.
Publication year - 2018
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/jfb.13564
Subject(s) - danio , biology , zebrafish , retinoic acid , oogenesis , gene isoform , transcriptome , microbiology and biotechnology , downregulation and upregulation , gonad , gene expression , gene , genetics , oocyte , endocrinology , embryo
The expression pattern of genes coding for enzymes of the retinoic acid (RA) synthetic and degradation pathways was characterized in adult female zebrafish Danio rerio . Females were conditioned until maturation and post‐spawn expression dynamics were determined. A striking upregulation of cyp26b1 , but not cyp26a1 , was observed following egg deposition, decreasing to initial levels during recovery. A similar, yet lower, fluctuation was observed for aldh1a2 and rdh10a , the enzymes participating in the two‐step RA biosynthesis cascade. The present work highlights the dynamics of the adult D. rerio oogenesis and uncovers novel, yet elusive, metabolic contributors. Possible compartmentalized roles for the different gene paralogue isoforms are discussed.