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Expression profile of oestrogen receptors and oestrogen‐related receptors is organ specific and sex dependent: the Japanese medaka Oryzias latipes model
Author(s) -
Cheung N. K. M.,
Cheung A. C. K.,
Ye R. R.,
Ge W.,
Giesy J. P.,
Au D. W. T.
Publication year - 2013
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1111/jfb.12164
Subject(s) - oryzias , biology , gene isoform , oestrogen receptor , receptor , estrogen receptor , gene , medicine , genetics , cancer , breast cancer
Gene expression of all known subtypes of oestrogen receptor ( ER ) and oestrogen‐related receptor ( ERR ) in multiple organs and both sexes of the Japanese medaka Oryzias latipes was profiled and systematically analysed. As revealed by statistical analyses and low‐dimensional projections, the expressions of ERRs proved to be organ and sex dependent, which is in contrast with the ubiquitous nature of ERs . Moreover, expressions of specific ERR isoforms ( ERRγ1 , ERRγ2 ) were strongly correlated with that of all ERs ( ERα , ERβ1 and ERβ2 ), suggesting the existence of potential interactions. Findings of this study shed light on the co‐regulatory role of particular ERRs in oestrogen‐ ERs signalling and highlight the potential importance of ERRs in determining organ and sex‐specific oestrogen responses. Using O. latipes as an alternative vertebrate model, this study provides new directions that call for collective efforts from the scientific community to unravel the mechanistic action of ER‐ERR cross‐talks, and their intertwining functions, in a cell and sex‐specific manner in vivo .