Premium
Microsporidia Can Acquire Lamin‐like Intermediate Filaments and Cell Adhesion Catenin‐cadherin Complexes from the Host (?)
Author(s) -
Weidner Earl,
Sokolova Yuliya Y.,
Overstreet Robin M.
Publication year - 2020
Publication title -
journal of eukaryotic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 1066-5234
DOI - 10.1111/jeu.12811
Subject(s) - biology , lamin , microsporidia , cytoplasm , microbiology and biotechnology , cadherin , catenin , host (biology) , adhesion , microtubule , intermediate filament , cell adhesion , spore , cytoskeleton , cell , genetics , nucleus , botany , wnt signaling pathway , signal transduction , chemistry , organic chemistry
On their spore surfaces, Microsporidia often develop a canopy of filaments with characteristics of intermediate filaments ( IF ), as we demonstrated in previous studies on Thelohania sp., Ameson michaelis, and S praguea lophii . Genomic studies indicate that among invertebrates, lamins that may localize in the cytoplasm or nucleus, are the only known IF type. These IF s can bind to the substrate containing cell adhesion molecules ( CAM s) cadherins, associated with β and γ catenins. The objects of this study were to determine whether microsporidia have CAM s with the attached IF s on their envelopes and to find out if these proteins are provided by the host. An examination was made for localization of lamins and CAM s on the spores of the mentioned above species and Anncaliia algerae, plus in the host animals. Then, we determined whether the spores of A. michaelis and A. algerae could bind vertebrate nuclear lamin onto the spore surface. We also tested transgenic Drosophila melanogaster stocks bearing cadherin‐ GFP to see whether developing A. algerae parasites in these hosts could acquire host CAM s. The tests were positive for all these experiments. We hypothesize that microsporidia are able to acquire host lamin IF s and cell adhesion catenin–cadherin complexes from the host.