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Inflammatory markers IL‐1β and RANK‐L assessment after non‐vital bleaching: A 3‐month follow‐up
Author(s) -
Bersezio Cristian,
Sánchez Francisca,
Estay Juan,
Ledezma Paulina,
Vernal Rolando,
Garlet Gustavo,
Oliveira Osmir Batista,
Fernández Eduardo
Publication year - 2020
Publication title -
journal of esthetic and restorative dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.919
H-Index - 60
eISSN - 1708-8240
pISSN - 1496-4155
DOI - 10.1111/jerd.12557
Subject(s) - carbamide peroxide , bleach , dentistry , medicine , hydrogen peroxide , statistical significance , chemistry , enamel paint , organic chemistry
Objective This study assessed IL‐1β and RANK‐L levels in vivo and color stability of non‐vital teeth bleached using hydrogen (35%) and carbamide (37%) peroxides 3 months after treatment. Materials and Methods Fifty teeth were randomly divided into two groups(n = 25):35% hydrogen peroxide (HP) or 37% carbamide peroxide (CP). Four sessions of intracoronal walking‐bleach procedure were performed. IL‐1β and RANK‐L levels were assessed from gingival crevicular fluid samples (from three vestibular and three palatines sites) at eight different time‐points: at the beginning of the study (baseline), after four sessions of intracanal bleaching, and at 1 week, 1 month, and 3 months posttreatment. The color variations were visually detected using Vita bleach shade guide (ΔSGU). Results Significant increases of IL‐1β and RANK‐L levels were detected at all time‐points (all P < .05) when comparing each time‐point to baseline, and a high correlation (>0.8—Spearman) between variables. According the ΔSGU values, a color change of five for HP and four for CP were detected. Conclusions Non‐vital walking bleach technique promotes an increase in IL‐1β and RANKL levels in periodontal tissues and also, it is maintained until the third‐month posttreatment. Clinical Significance The internal whitening of teeth increases the levels of cytokines associated with inflammation and bone resorption 3 months after the whitening procedure is finished; this should warn of possible harmful effects of this whitening technique.