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Haemoglobin levels correlates with the presence of coronary artery disease
Author(s) -
Doganer Yusuf C.,
Rohrer James E.,
Aydogan Umit,
Bernard Matthew E.,
Barcin Cem
Publication year - 2015
Publication title -
journal of evaluation in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.737
H-Index - 73
eISSN - 1365-2753
pISSN - 1356-1294
DOI - 10.1111/jep.12409
Subject(s) - quartile , medicine , coronary artery disease , diabetes mellitus , odds ratio , coronary angiography , gastroenterology , myocardial infarction , confidence interval , endocrinology
Rationale, aims and objectives Although the condition of low haemoglobin ( H b) levels has been established as a risk factor in the development of coronary artery disease ( CAD ), it is still a debate particularly in patients with angiographically documented disease. In the present study, we sought to identify the relationship between H b levels and the presence of CAD . Methods The study consisted of 356 consecutive patients referred for elective coronary angiography ( CAG ). Exclusion criteria included a history of prior MI within last 3 months, presence of neoplastic disorders or any inflammatory diseases or overt diabetes mellitus. Blood samples for haematologic and biochemical measurements were collected on admission following at least 12 hours of overnight fasting. Patients were divided into four groups based on the quartiles of H b (quartile I < 13.50 g/dL, quartile II 13.50–14.70 g/dL, quartile III 14.71–15.74 g/dL, quartile IV > 15.74 g/dL). Additionally, patients filled out a questionnaire of asking their brief medical histories and baseline characteristics. Results Lower Hb quartiles were independently related to the presence of CAD in subjects who were referred to elective CAG . The patients with older age [ P = 0.008, odds ratio ( OR ) = 1.042], male gender ( P = 0.007, OR = 3.408), in quartile I ( P = 0.003, OR = 5.697), in quartile II ( P < 0.001, OR = 8.767), in quartile III ( P = 0.011, P = 3.076), higher white blood cells count ( P = 0.037, OR = 1.208), lower platelet count ( P = 0.049, OR = 0.995), condition of current smoker ( P = 0.030, OR = 2.548), higher value of fasting glucose ( P = 0.014, OR = 1.038), estimated glomerular filtration rate < 60 (mL/min/1.73 m 2 ; P = 0.004, OR = 3.269) were more likely associated with the risk of the presence of CAD . Conclusions The present study revealed that lower quartiles of H b levels were independently related to the presence of CAD in subjects who were referred to elective CAG . H b levels, which can be measured easily in almost all medical centres, may be considered as a potential predictor for the presence of CAD in patients at high risk for CAD .