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ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
Author(s) -
Wang JingQuan,
Wu ZhuoXun,
Yang Yuqi,
Teng QiuXu,
Li YiDong,
Lei ZiNing,
Jani Khushboo A,
Kaushal Neeraj,
Chen ZheSheng
Publication year - 2021
Publication title -
journal of evidence‐based medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.885
H-Index - 22
ISSN - 1756-5391
DOI - 10.1111/jebm.12434
Subject(s) - atp binding cassette transporter , efflux , transporter , biology , multiple drug resistance , abcg2 , computational biology , function (biology) , membrane transport protein , drug resistance , biochemistry , microbiology and biotechnology , genetics , gene
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane protein families existing in wide spectrum of organisms from prokaryotes to human. ABC transporters are also known as efflux pumps because they mediate the cross‐membrane transportation of various endo‐ and xenobiotic molecules energized by ATP hydrolysis. Therefore, ABC transporters have been considered closely to multidrug resistance (MDR) in cancer, where the efflux of structurally distinct chemotherapeutic drugs causes reduced itherapeutic efficacy. Besides, ABC transporters also play other critical biological roles in cancer such as signal transduction. During the past decades, extensive efforts have been made in understanding the structure‐function relationship, transportation profile of ABC transporters, as well as the possibility to overcome MDR via targeting these transporters. In this review, we discuss the most recent knowledge regarding ABC transporters and cancer drug resistance in order to provide insights for the development of more effective therapies.