Premium
Celiac disease and risk of sarcoidosis: A systematic review and meta‐analysis
Author(s) -
Wijarnpreecha Karn,
Panjawatanan Panadeekarn,
Corral Juan E.,
Lukens Frank J.,
Ungprasert Patompong
Publication year - 2019
Publication title -
journal of evidence‐based medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.885
H-Index - 22
ISSN - 1756-5391
DOI - 10.1111/jebm.12355
Subject(s) - meta analysis , medicine , odds ratio , disease , sarcoidosis , confidence interval , medline , study heterogeneity , relative risk , political science , law
Background/objectives Several epidemiologic studies have suggested that patients with celiac disease may be at an increased risk of sarcoidosis but the results were inconsistent. This systematic review and meta‐analysis was conducted with the aim to better characterize this risk by summarizing all available data. Methods A literature review was performed using MEDLINE and EMBASE database from inception to February 2019. Studies that compared the risk of sarcoidosis among patients with celiac disease versus individuals without celiac disease were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random‐effect, generic inverse variance method. Results Of 426 retrieved studies, four studies with 693 639 participants met the eligibility criteria and were included in meta‐analysis. The risk of sarcoidosis among patients with celiac disease was higher than individuals without celiac disease with the pooled OR of 7.16 (95% CI, 1.48‐34.56). The statistical heterogeneity of this study was high (I 2 = 95%). Conclusions This systematic review and meta‐analysis found a significantly higher risk of sarcoidosis among patients with celiac disease.