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The effects of contrast media volume on acute kidney injury after transcatheter aortic valve replacement: a systematic review and meta‐analysis
Author(s) -
Thongprayoon Charat,
Cheungpasitporn Wisit,
Podboy Alexander J.,
Gillaspie Erin A.,
Greason Kevin L.,
Kashani Kianoush B.
Publication year - 2016
Publication title -
journal of evidence‐based medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.885
H-Index - 22
ISSN - 1756-5391
DOI - 10.1111/jebm.12208
Subject(s) - medicine , acute kidney injury , hazard ratio , meta analysis , odds ratio , valve replacement , confidence interval , relative risk , aortic valve replacement , cardiology , surgery , stenosis
Objective The goal of this systematic review was to assess the effects of contrast media volume on transcatheter aortic valve replacement‐related acute kidney injury. Methods A literature search was performed using Medline, EMbase, the Cochrane Database of Systematic Reviews, and clinicaltrials.gov from the inception of these databases through December 2015. Studies that reported relative risk, odds ratio, or hazard ratio comparing the risks of acute kidney injury following transcatheter aortic valve replacement in patients who received high contrast media volume were included. Pooled risk ratio (RR) and 95% confidence intervals (95% CI) were calculated using a random‐effect, generic inverse variance method. Results Four cohort studies composed of 891 patients were included in the analyses to assess the risk of acute kidney injury after transcatheter aortic valve replacement in patients who received high contrast media volume. The pooled RR of acute kidney injury after transcatheter aortic valve replacement in patients who received a large volume of contrast media was 1.41 (95% CI, 0.87 to 2.28) compared with low contrast media volume. The meta‐analysis was limited to studies using standard acute kidney injury definitions, and the pooled RR of acute kidney injury in patients who received high contrast media volume is 1.12 (95% CI, 0.78 to 1.62). Conclusion Our meta‐analysis shows no significant association between contrast media volume and risk of acute kidney injury after transcatheter aortic valve replacement.