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High‐intensity focused ultrasound for treatment of pancreatic cancer: a systematic review
Author(s) -
Li Cui Cui,
Wang Ying Qiang,
Li You Ping,
Li Xiang Lian
Publication year - 2014
Publication title -
journal of evidence‐based medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.885
H-Index - 22
ISSN - 1756-5391
DOI - 10.1111/jebm.12128
Subject(s) - medicine , gemcitabine , high intensity focused ultrasound , cochrane library , adverse effect , randomized controlled trial , pancreatic cancer , meta analysis , oncology , clinical trial , inclusion and exclusion criteria , radiation therapy , cancer , ultrasound , radiology , pathology , alternative medicine
Objective To explore the efficacy and safety of high‐intensity focused ultrasound combined with other physical therapies for the treatment of pancreatic cancer, so as to provide reference for clinical application. Methods The PubMed, EMbase, The Cochrane Library (Issue 11, 2013), CBM, CNKI, and WanFang databases were systematically searched up to November 2013. The randomized controlled trials and clinical controlled trials about the treatment of high‐intensity focused ultrasound were included. According to the inclusion and exclusion criteria, two reviewers independently screened the studies, exacted the data, and assessed the quality. The meta‐analysis was performed by using the RevMan 5.0 software. Results A total of 23 studies including 19 randomized controlled trials and four clinical controlled trials were included. Of which 14 studies reported the safety. The results of meta‐analyses showed that: the survival rate at 6 months and 12 months, overall efficacy, and clinical benefit rate in high‐intensity focused ultrasound plus radiation and chemotherapy group were significantly higher than those in groups treated with three‐dimensional conformal radiation therapy (P < 0.05), gemcitabine (P < 0.05), gemcitabine plus cisplatin (P < 0.05), and gemcitabine plus 5‐fluorouracil (P < 0.05). The adverse effect caused by high‐intensity focused ultrasound plus other therapy was equal to those in the control group. The major high‐intensity focused ultrasound‐related adverse effect was skin damage and fever. Conclusion The current evidence suggested that the efficacy of HIFU for pancreatic cancer was superior to other therapies, but with poor quality. Therefore, a standard and unified criterion for the diagnosis and outcome measures of pancreatic cancer is needed, and the quality of study design and implementation should be bettered, so as to improve the high quality of evidence for its clinical application.