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Resistance to natural and synthetic gene drive systems
Author(s) -
Price Tom A. R.,
Windbichler Nikolai,
Unckless Robert L.,
Sutter Andreas,
Runge JanNiklas,
Ross Perran A.,
Pomiankowski Andrew,
Nuckolls Nicole L.,
MontchampMoreau Catherine,
Mideo Nicole,
Martin Oliver Y.,
Manser Andri,
Legros Mathieu,
Larracuente Amanda M.,
Holman Luke,
Godwin John,
Gemmell Neil,
Courret Cécile,
Buchman Anna,
Barrett Luke G.,
Lindholm Anna K.
Publication year - 2020
Publication title -
journal of evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.289
H-Index - 128
eISSN - 1420-9101
pISSN - 1010-061X
DOI - 10.1111/jeb.13693
Subject(s) - biology , gene drive , gene , natural (archaeology) , computational biology , synthetic biology , resistance (ecology) , natural selection , genetics , microbiology and biotechnology , crispr , ecology , selection (genetic algorithm) , computer science , paleontology , artificial intelligence
Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.