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Risk of connective tissue disease, morphoea and systemic vasculitis in patients with hidradenitis suppurativa
Author(s) -
Schneeweiss M.C.,
Merola J.F.,
Schneeweiss S.,
Wyss R.,
Rosmarin D.
Publication year - 2021
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.16728
Subject(s) - medicine , hidradenitis suppurativa , systemic vasculitis , systemic disease , vasculitis , connective tissue disease , ctd , systemic scleroderma , mixed connective tissue disease , rheumatology , population , dermatology , scleroderma (fungus) , pathology , disease , autoimmune disease , oceanography , environmental health , inoculation , geology
Background Hidradenitis suppurativa (HS) has been associated with auto‐inflammatory conditions, yet the risk of developing connective tissue disease (CTD), morphoea and systemic vasculitis has not been well‐characterized. Objectives We sought to evaluate the risk of developing CTD, morphoea and systemic vasculitis in patients with HS. Methods Using claims data, we identified patients with HS and used 2 : 1 risk‐set sampling to identify patients without HS. Patients with existing CTD were excluded. Patient follow‐up lasted until first occurrence of the following events: the occurrence of outcome (i.e. systemic lupus erythematosus, morphoea, systemic sclerosis, Sjogren’s Syndrome and systemic vasculitis), death, disenrolment or end of data stream. Hazard ratios (HR) of developing CTD, morphoea and systemic vasculitis were computed after 1 : 1 propensity score (PS) matching. Results After 2 : 1 risk‐set sampling, we identified 78 122 HS patients and 156 247 non‐HS comparators. The mean follow‐up was 540 days. After PS matching, HS patients had an increased risk of systemic lupus erythematosus HR = 1.63 (1.31–2.03) and morphoea HR = 2.02 (1.32–3.11), compared to non‐HS patients. We did not observe an increased risk for systemic sclerosis HR = 0.90 (0.59–1.44), Sjogren’s Syndrome HR = 0.91 (0.73–1.14) or systemic vasculitis HR = 0.87 (0.64–1.20). Conclusion In this population‐based study, we observed an increased risk of developing systemic lupus erythematous and morphoea subsequent to a first‐recorded diagnosis of hidradenitis suppurativa.