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Additional pharmacological activity of I‐modulia and generation of two newly designed extracts of Aquaphilus dolomiae culture for dermocosmetic actives
Author(s) -
Nguyen T.,
Chol B.,
Maitre M.,
RavardHelffer K.,
Farinole F.,
Lestienne F.,
CastexRizzi N.
Publication year - 2020
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.16546
Subject(s) - medicine , degranulation , in vitro , ex vivo , immune system , immune modulation , pharmacology , in vivo , inflammation , cell culture , immunology , traditional medicine , biochemistry , microbiology and biotechnology , receptor , biology , genetics
Aquaphilus dolomiae (AD) is a unique isolate from Avène Thermal Spring Water. I‐Modulia, the first biotech extract from culture of AD, was used as immune modulator in Th2 inflammatory models. In this short publication, firstly we describe generation of two AD de novo extracts specifically designed for repairing and for neuroinflammation modulation activities which will be described, respectively, in two other articles in this supplement. Finally, for I‐modulia, we describe new data on inhibition of human mast cell degranulation in vitro and its effect on substance P‐induced neurogenic inflammation on ex vivo human skin explants.