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Lymphomatoid papulosis: an update and review
Author(s) -
MartinezCabriales S.A.,
Walsh S.,
Sade S.,
Shear N.H.
Publication year - 2020
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.15931
Subject(s) - lymphomatoid papulosis , medicine , mycosis fungoides , anaplastic large cell lymphoma , lymphoproliferative disorders , differential diagnosis , pathology , dermatology , lymphoma , immunophenotyping , histology , cd43 , immunology , antigen , cd20
Lymphomatoid papulosis (LyP) is a benign chronic often relapsing skin condition that belongs to the CD 30‐positive cutaneous lymphoproliferative disorders. LyP typically presents as crops of lesions with a tendency to self‐resolve, and morphology can range from solitary to agminated or diffuse papules and plaques to nodules or tumours. The clinical–histological spectrum can range from borderline cases to overlap with primary cutaneous anaplastic cell lymphoma (pc ALCL ). Histology and immunophenotype commonly show overlap with other CD 30‐positive disorders and sometimes may be identical to pc ALCL , making its diagnosis more difficult. Patients with LyP have an increased risk of developing a second neoplasm such as mycosis fungoides, pc ALCL and/or Hodgkin lymphoma. Clinical correlation allows its proper classification and diagnosis, which is fundamental for treatment and prognosis. This review focuses on the clinical appearance, histopathological features, diagnosis, differential diagnosis and management of LyP.