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Age‐specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children
Author(s) -
Bucchia M.,
Barbarot S.,
Reumaux H.,
Piram M.,
Mahe E.,
Mallet S.,
Balguerie X.,
Phan A.,
Lacour J.P.,
Decramer S.,
Hatchuel Y.,
Jean S.,
Begon E.,
Joubert A.,
Merlin E.,
Wallach D.,
Meinzer U.,
Bourrat E.
Publication year - 2019
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.15730
Subject(s) - medicine , dermatology , pediatrics
Background Our suggested ‘modern’ concepts of ‘neutrophilic dermatoses’ ( ND ) and ‘neutrophilic disease’ were based on observations in adult patients and have not been studied in paediatric patients. Only a minority of ND occurs in children, and little is known about age‐specific characteristics. Objectives To describe age‐specific characteristics of ND in children and to study whether our suggested ‘modern’ classification of ND may be applied to children. Methods We conducted a retrospective multicentre study in a French cohort of 27 paediatric patients diagnosed with pyoderma gangrenosum ( PG ) or Sweet's syndrome ( SS ). Results Demographics and distribution of typical/atypical forms were similar in patients diagnosed with PG and SS . Atypical ND were more frequent in infants (90%), when compared to young children (60%) and adolescents (33%). Neutrophilic disease was observed in 17/27 patients and was most frequent in infants. Neutrophilic disease of the upper respiratory tract, as well as cardiac neutrophilic disease, was only observed in infants, whereas other locations were similarly found in infants, young children and adolescents. In infants and young children, ND were associated with a large spectrum of general diseases, whereas in adolescents associations were limited to inflammatory bowel disease and Behçet's disease. Conclusions Our study describes the concept of ND in paediatric patients and shows that they have some characteristics different from ND occurring in adults. ND occurring in infants can be associated with a large spectrum of general diseases. Occurrence of neutrophilic disease is frequent in children. Thus, ND occurring in young paediatric patients should incite clinicians to schedule complementary explorations in order to search for involvement of other organs and to rule out monogenetic autoinflammatory syndromes.