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Atopic dermatitis and the metabolic syndrome: a cross‐sectional study of 116 816 patients
Author(s) -
Shalom G.,
Dreiher J.,
Kridin K.,
Horev A.,
Khoury R.,
Battat E.,
Freud T.,
Comaneshter D.,
Cohen A.D.
Publication year - 2019
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.15642
Subject(s) - medicine , metabolic syndrome , atopic dermatitis , diabetes mellitus , obesity , cross sectional study , population , multivariate analysis , gastroenterology , dermatology , endocrinology , pathology , environmental health
Background Data regarding the association between atopic dermatitis ( AD ) and the metabolic syndrome are controversial. Objective To evaluate the prevalence of the metabolic syndrome and its components in a large group of patients with AD compared to a matched reference group. Methods A cross‐sectional study of AD patients diagnosed by a dermatologist between 1998 and 2016, and a matched comparison group was performed. We analysed the association between AD and metabolic syndrome, its components and possible complications for the entire study population, adults (age > 18) and adults with moderate‐to‐severe AD . Results The study included 116 816 patients with AD and 116 812 comparison enrollees. AD in the entire group of patients and in the adult patients was associated with a higher prevalence of dyslipidaemia and a lower prevalence of diabetes and metabolic syndrome. Moderate and severe AD were associated, respectively, with higher prevalence rates of the metabolic syndrome (17.0% vs. 9.4%), its components (obesity: 22.2% vs. 18.6%; diabetes: 15.9% vs. 9.2%; hypertension 27.9% vs. 15.3%; dyslipidaemia 47.1% vs. 28.5%, all P values < 0.001) and cardiovascular morbidity (all P values < 0.001). Multivariate analysis demonstrated a significant overrepresentation of the metabolic syndrome in moderate‐to‐severe AD ( P = 0.04). Conclusions Severely affected patients with AD may have one or more undiagnosed components of metabolic syndrome.