Effectiveness, safety and tolerability of drainage and punch‐trocar‐assisted cryoinsufflation (cryopunch) in the treatment of inflammatory acute fluid collections in hidradenitis suppurativa patients

chosis, palmoplantar keratoderma or hyperkeratosis and nail abnormalities in 4%, 6% and 22% of the cases, respectively). Kellermayer et al. reported a case with hyperkeratotic plaques at friction area associated with universalis alopecia and onychodystrophy resembling our cases but no leukonychia or hyperostosis. The patient had inherited heterozygous mutation of GJB2 and de novo heterozygous GJA1 mutation, p.Val41Leu. Thanks to exome sequencing, Wang et al. identified a de novo p.Gly8Val GJA1 mutation in two unrelated index patients and the daughter of one of them with total leukonychia, alopecia of the scalp, eyebrows and eyelashes associated with hyperkeratosis on friction areas, diffuse keratosis pilaris and focal but transgredient palmoplantar keratoderma but no hyperostosis. Boyden et al. identified a dominant de novo p.Glu227Asp and p.Ala44Val GJA1 mutation in three unrelated patients with hyperkeratotic lesions on frictional areas with palmoplantar keratoderma but no hyperostosis. Up to the present publication, neither the severe cutaneous phenotypes associated with GJA1 mutations were associated with features of ODD syndrome nor the patients with typical ODD had severe cutaneous phenotype. Furthermore, no such nerve compression has been previously described.