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Four compartment method as an efficacious and simplified technique for autologous non‐cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active‐controlled study
Author(s) -
Mrigpuri S.,
Razmi T M.,
Sendhil Kumaran M.,
Vinay K.,
Srivastava N.,
Parsad D.
Publication year - 2019
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.15234
Subject(s) - vitiligo , medicine , surgery , refractory (planetary science) , randomized controlled trial , clinical efficacy , dermatology , compartment (ship) , physics , astrobiology , oceanography , geology
Background Autologous non‐cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts its use to only a few research centres; hence, there is a requisite to simplify the technique of NCES preparation. Objectives To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory‐based method (lab‐NCES). Methods Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab‐NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation. Results Repigmentation outcome in 4C method as compared to lab‐NCES was as follows: excellent (≥90%) repigmentation: 34% vs. 37%, P = 1.000, good (≥75%) repigmentation: 68% vs. 71%, P = 1.000; colour match: 59% vs. 54%, P = 0.794, patient satisfaction based on PGA score – 23.02 vs. 23.39 ( P = 0.210) and major pattern of repigmentation (diffuse) – 76% vs. 71% ( P = 0.618). Limitations Short follow‐up period of 16 weeks. Conclusion Four compartment method is a simple and effective technique for vitiligo surgery in routine clinical practice.