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Which acne treatment has the best influence on health‐related quality of life? Literature review by the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes
Author(s) -
Chernyshov P.V.,
TomasAragones L.,
Manolache L.,
Svensson A.,
Marron S.E.,
Evers A.W.M.,
Bettoli V.,
Jemec G.B.,
Szepietowski J.C.
Publication year - 2018
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.15048
Subject(s) - medicine , acne , venereology , isotretinoin , dermatology , quality of life (healthcare) , dermatology life quality index , rosacea , benzoyl peroxide , adapalene , hidradenitis suppurativa , psoriasis , disease , chemistry , nursing , organic chemistry , polymerization , polymer
Abstract According to results of a recent literature search performed by the European Academy of Dermatology and Venereology ( EADV ) Task Forces ( TF ) on Quality of Life and Patient Oriented Outcomes (QoL and PO ) and Acne, Rosacea and Hidradenitis Suppurativa ( ARHS ), most of the publications where health‐related ( HR ) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO decided to detect which acne treatment has the best influence on HRQ oL of acne patients. A new literature search was organized to find publications on acne treatment where the HRQ oL of patients was assessed as an outcome measure. From 186 papers with HRQ oL assessment, 37 papers were included for further analysis. Our results revealed that oral isotretinoin had the best influence on HRQ oL of acne patients. Several other treatment methods also showed good effects on the HRQ oL of acne patients. Oral isotretinoin and norethindrone acetate/ethinyl estradiol, topical clindamycin phosphate/benzoyl peroxide and adapalene/benzoyl peroxide showed significantly better effect on HRQ oL than placebo. There is limited number of the high‐quality studies on acne treatment where HRQ oL was assessed. Dermatology‐specific and acne‐specific instruments showed much better sensitivity to successful therapeutic intervention than generic HRQ oL instruments. The most frequently used HRQ oL instrument was the Dermatology Life Quality Index questionnaire.