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Psoriasis and cardiovascular disease risk factors: the HUNT Study, Norway
Author(s) -
Snekvik I.,
Nilsen T.I.L.,
Romundstad P.R.,
Saunes M.
Publication year - 2018
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.14835
Subject(s) - medicine , psoriasis , odds ratio , population , body mass index , overweight , metabolic syndrome , disease , diabetes mellitus , cross sectional study , waist , confidence interval , obesity , dermatology , endocrinology , pathology , environmental health
Background Studies have examined the associations between psoriasis and cardiovascular diseases and their risk factors, but the results are conflicting, especially in the general population. Objectives To investigate the association of psoriasis, and in particular psoriasis severity, with objectively measured cardiovascular disease risk factors and cardiovascular morbidity in a large population‐based cross‐sectional study. Methods We linked data on 50 245 persons in the HUNT 3 Study, Norway, with information from the National Prescription Database to obtain information on use of psoriasis medication. A total of 2894 persons reported to have psoriasis; 2643 were classified as mild; and 251 as moderate/severe psoriasis. We used linear and logistic regression to estimate adjusted associations with 95% confidence intervals ( CI s) between psoriasis and cardiovascular disease risk factors and morbidity. Results We observed a positive association between psoriasis and objective measures of body mass index ( BMI ), waist circumference and high‐sensitivity C‐reactive protein, but no clear association with blood pressure and blood lipids. People with moderate/severe psoriasis had an odds ratio for being overweight of 1.94 (95% CI 1.42, 2.67), whereas the odds ratio for metabolic syndrome was 1.91 (95% CI 1.47, 2.49). Psoriasis was also positively associated with self‐reported diabetes, myocardial infarction and angina pectoris. Conclusions In this population‐based study, we found that psoriasis was positively associated with measures of adiposity, as well as with a clustering of cardiovascular disease risk factors. Overall, these associations were strongest for people with moderate/severe psoriasis.