Premium
Distinctive cutaneous and systemic features associated with specific antimyositis antibodies in adults with dermatomyositis: a prospective multicentric study of 117 patients
Author(s) -
Best M.,
Jachiet M.,
Molinari N.,
Manna F.,
Girard C.,
Pallure V.,
Cosnes A.,
Lipsker D.,
Hubiche T.,
Schmutz J.L.,
Le Corre Y.,
Cordel N.,
Dandurand M.,
Dereure O.,
Guillot B.,
DuThanh A.,
Bulai Livideanu C.,
Chasset F.,
Bouaziz J.D.,
Francès C.,
Bengoufa D.,
Vincent T.,
Bessis D.
Publication year - 2018
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.14759
Subject(s) - medicine , dermatomyositis , calcinosis , autoantibody , myositis , interstitial lung disease , cancer , dermatology , dlco , pathology , lung cancer , connective tissue disease , anti nuclear antibody , antibody , disease , immunology , autoimmune disease , lung , calcification , lung function , diffusing capacity
Background Identification of myositis‐specific autoantibodies ( MSA s) for dermatomyositis ( DM ) could allow the characterization of an antibody‐associated clinical phenotype. Objective We sought to define the clinical phenotype of DM and the risk of cancer, interstitial lung disease ( ILD ) and calcinosis based on MSA . Methods A 3.5‐year multicentre prospective study of adult DM patients was conducted to determine the clinical phenotype associated with MSA s and the presence of cancer, ILD and calcinosis. Results MSA s were detected in 47.1% of 117 included patients. Patients with antimelanoma differentiation‐associated protein‐5 antibodies (13.7%) had significantly more palmar violaceous macules/papules [odds ratio ( OR ) 9.9], mechanic's hands ( OR 8), cutaneous necrosis ( OR 3.2), articular involvement ( OR 15.2) and a higher risk of ILD ( OR 25.3). Patients with antitranscriptional intermediary factor‐1 antibodies (11.1%), antinuclear matrix protein‐2 antibodies (6.8%) and antiaminoacyl‐transfer RNA synthetase (5.1%) had, respectively, significantly more poikiloderma ( OR 5.9), calcinosis ( OR 9.8) and articular involvement ( OR 15.2). Cutaneous necrosis was the only clinical manifestation significantly associated with cancer ( OR 3.1). Conclusion Recognition of the adult DM phenotype associated with MSA s would allow more accurate appraisal of the risk of cancer, ILD and calcinosis.