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Atopic dermatitis is inversely associated with hepatitis B antigen positivity: a population‐based cohort study
Author(s) -
Kim H.Y.,
Kim C.W.,
Choi J.Y.,
Yu D.S.,
Kim J.W.,
Han K.D.,
Park Y.G.,
Lee Y.B.
Publication year - 2017
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.14428
Subject(s) - medicine , national health and nutrition examination survey , asthma , odds ratio , atopic dermatitis , hepatitis b virus , atopy , cross sectional study , hepatitis b , population , logistic regression , immunology , gastroenterology , virus , environmental health , pathology
Background No clear association between hepatitis B virus ( HBV ) infection and atopic dermatitis ( AD ) has been established. Some studies have reported that subjects with HBV had an increased risk of atopy; other studies reported an inverse association between HBV seropositivity and allergic diseases. Objective We evaluated the association between AD and hepatitis B antigen ( HB sAg) positivity using Korean National Health and Nutrition Examination Survey data. Methods In total, 14 776 participants aged >19 years were included in the analysis. Multiple logistic regression analyses were used to evaluate the odds ratio of HB sAg positivity in association with AD and asthma. Results The prevalence of HB sAg positivity was lower in individuals with AD than in those without AD (mean [ SE ], 0.7% [0.4] vs. 3.7% [0.2]; P < 0.001). However, HB sAg positivity was not significantly associated with asthma (3.7% [0.2] vs. 2.8% [0.8]; P < 0.001). HB sAg positivity decreased the risk of AD significantly ( OR = 0.223; 95% CI = 0.069–0.72). Conclusions This study demonstrates an inverse association between AD and HB sAg positivity using a nationwide, population‐based, cross‐sectional health examination and survey.