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Increased expression of the interleukin‐36 cytokines in lesions of hidradenitis suppurativa
Author(s) -
Thomi R.,
Kakeda M.,
Yawalkar N.,
Schlapbach C.,
Hunger R.E.
Publication year - 2017
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.14389
Subject(s) - hidradenitis suppurativa , medicine , pathogenesis , interleukin , proinflammatory cytokine , psoriasis , downregulation and upregulation , immunology , interleukin 18 , cytokine , tumor necrosis factor alpha , inflammation , disease , gene , biology , biochemistry
Background Hidradenitis suppurativa ( HS ) is a recalcitrant chronic skin disease with poorly understood immunopathogenic mechanisms. Previous studies reported that the interleukin‐36 ( IL ‐36) cytokines [ IL ‐36α, IL ‐36β, IL ‐36γ and IL ‐36 receptor antagonists ( IL ‐36 RA )] are important players in the pathogenesis of psoriasis ( PS ). Objective We aim to determine whether the IL ‐36 cytokines are upregulated in patients with HS . For this purpose, we analysed local expression and systemic levels of the IL ‐36 cytokines in patients with HS and compared the results to healthy donors and patients with PS . Methods Skin biopsies from healthy donors and HS and PS patients were analysed for expression of the IL ‐36 cytokines by immunohistochemistry and semiquantitative real‐time PCR . The enzyme‐linked immunosorbent assay ( ELISA ) was used to measure systemic levels of the IL ‐36 cytokines in the serum of the three donor groups. Results The agonists IL ‐36α, IL ‐36β and IL ‐36γ were found to be upregulated in HS both systemically and lesionally, while the IL ‐36 RA was not differently regulated in comparison to healthy donors. Conclusion Our findings suggest that the agonistic IL ‐36 isoforms are upregulated in HS . The relevance of the enhanced production of IL ‐36 cytokines in HS pathogenesis remains to be determined.