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Atopic dermatitis IL 17A‐ and IFN ‐γ‐producing lymphocytes: investigation in blood, chronic lesions and APT
Author(s) -
Grieco T.,
Faina V.,
Porzia A.,
Paolino G.,
Morrone S.,
Bottoni U.,
Calvieri S.,
Mainiero F.
Publication year - 2017
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.14258
Subject(s) - medicine , atopic dermatitis , university hospital , dermatology , family medicine
Recent findings suggest that an imbalance of Th1, Th2 and Treg plays a critical role in the pathogenesis of AD and that CD8+ T cells are required for the development of AD lesions.[1, 2]\ud\udWe studied the phenotype of peripheral blood (PB) circulating and intraepithelial lymphocytes deriving from skin affected by chronic moderate–severe AD, acute reaction induced by an atopy patch test to Dermatophagoides spp (Dmix/APT) and in skin spared by AD